C–H deuteration of organic compounds and potential drug candidates
Gaurav Prakash, Nilanjan Paul, Gwyndaf A. Oliver, Daniel B. Werz, Debabrata Maiti
Abstract
This review summarises deuteration methods of various organic motifs containing C(sp 2 )−H and C(sp 3 )−H bonds utilizing C−H bond functionalisation as a key step along with a variety of catalysts, and exemplifies their biological relevance.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistryDrugDrug discoveryStereochemistryNanotechnologyOrganic chemistryMaterials scienceBiochemistryBiologyPharmacologyChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisCancer therapeutics and mechanisms