Herpesvirus of turkey-vectored avian influenza vaccine offers cross-protection against antigenically drifted H5Nx highly pathogenic avian influenza virus strains
Samir A. Nassif, Farid F. Zaki, Ahlam Mourad, Esraa Fouad, Asem Saad, Ahmed Setta, Balázs Felföldi, Tamás Mató, István Kiss, Vilmos Palya
Abstract
reduction in the amount of excreted virus following challenge with H5N1, H5N2 and H5N8 viruses, respectively. Analyses of the amino acid sequences of the HA proteins of challenge viruses and serological relatedness with the vaccine insert revealed significant antigenic divergences between the vaccine and the challenge viruses. These results provide further evidence of the potential of HVT-based recombinant H5 vaccine to provide cross-protection against antigenically drifted HPAI H5Nx viruses with strong control on virus shedding.
Topics & Concepts
Influenza A virus subtype H5N1VirologyBiologyVirusViral sheddingH5N1 genetic structureSerologyMicrobiologyAntibodyImmunologyMedicineCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)PathologyInfluenza Virus Research StudiesAnimal Disease Management and EpidemiologyAnimal Virus Infections Studies