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Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation

Cai Shi, Boning Yang, Zhaolong He, Jingxiang Yang, Jingxiang Yang, Ling Li, Jian Song, Shiqiang Xu, Wei Song, Jian Yang, Jian Yang, Jian Yang, Jian Yang

2024European Journal of Medicinal Chemistry13 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIn vitroTubulinIn vivoApoptosisDocking (animal)MicrotubuleCell cycleCell cycle checkpointCell cultureStereochemistryPharmacologyBiochemistryCell biologyBiologyBiotechnologyNursingMedicineGeneticsQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms
Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation | Litcius