Update on lobular lesions of the breast
M. Gabriela Kuba, Edi Brogi
Abstract
The current histological classification of in-situ and invasive lobular carcinomas (ILCs) includes different morphological variants, some of which have been recently described. In this review, we will focus upon: (i) the diagnostic criteria of non-invasive lobular neoplasia and treatment implications across different countries; (ii) utility and limitations of immunohistochemistry; (iii) recently described variants of ILC; and (iv) the significance of lobular differentiation in invasive carcinoma for clinical management.
Topics & Concepts
Lobular carcinomaInvasive lobular carcinomaPathologyImmunohistochemistryMedicineBreast cancerCancerDuctal carcinomaInvasive ductal carcinomaInternal medicineBreast Lesions and CarcinomasBreast Cancer Treatment StudiesCancer and Skin Lesions