<i>anti</i>-Selective synthesis of β-boryl-α-amino acid derivatives by Cu-catalysed borylamination of α,β-unsaturated esters
Soshi Nishino, Yuji Nishii, Koji Hirano
Abstract
-diastereoselectivity (up to >99 : 1), which is difficult to obtain by the established methods. A chiral phosphoramidite ligand also successfully induces the enantioselectivity, giving the optically active β-borylated α-amino acids. The products can be stereospecifically transformed into β-functionalised α-amino acids, which are of potent interest in medicinal chemistry.
Topics & Concepts
ChemistryCombinatorial chemistryAmino acidOrganic chemistryBiochemistryOrganoboron and organosilicon chemistryChemical Synthesis and AnalysisAdvanced Synthetic Organic Chemistry