Loss of versican and production of hyaluronan in lung epithelial cells are associated with airway inflammation during RSV infection
Gerald G. Kellar, Kaitlyn A. Barrow, Lucille M. Rich, Jason S. Debley, Thomas N. Wight, Steven F. Ziegler, Stephen R. Reeves
Abstract
mice demonstrated enhanced recruitment of monocytes and neutrophils in bronchoalveolar lavage fluid and increased neutrophils in the lung compared with SPC-Cre(-) RSV-infected littermates. Taken together, these data demonstrate that altered extracellular matrix accumulation of HA occurs following RSV infection and may contribute to airway inflammation. In addition, loss of epithelial expression of versican promotes airway inflammation during RSV infection further demonstrating that versican's role in inflammatory regulation is complex and dependent on the microenvironment.
Topics & Concepts
VersicanInflammationImmunologyBronchoalveolar lavageExtracellular matrixRespiratory tractLungBiologyRespiratory systemMedicineCell biologyInternal medicineProteoglycanAnatomyProteoglycans and glycosaminoglycans researchRespiratory viral infections researchFibroblast Growth Factor Research