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A novel small-molecule antagonist enhances the sensitivity of osteosarcoma to cabozantinib in vitro and in vivo by targeting DNMT-1 correlated with disease severity in human patients

Ji‐Hai Wang, Zhen Zeng, Jie Sun, Yan Chen, Xudong Gao

2021Pharmacological Research42 citationsDOI

Topics & Concepts

CabozantinibOsteosarcomaIn vivoCancer researchAntagonistCell cultureSmall moleculeIn vitroMetastasisDNA methyltransferasePharmacologyChemistryInternal medicineMedicineMethyltransferaseBiologyCancerReceptorDNAGeneticsBiochemistryMethylationVEGF receptorsEpigenetics and DNA MethylationSarcoma Diagnosis and TreatmentHistone Deacetylase Inhibitors Research
A novel small-molecule antagonist enhances the sensitivity of osteosarcoma to cabozantinib in vitro and in vivo by targeting DNMT-1 correlated with disease severity in human patients | Litcius