Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide
Ali Bina, Heidar Raissi, Hassan Hashemzadeh, Farzaneh Farzad
Abstract
is the GOX/PMLA-hz-DOX complex at normal pH. On the other hand, this system has a great sensitivity to pH so that in an acidic environment, its interaction with GOX became weaker while such behavior is not observed for the PMLA-ami-DOX complex. The results obtained from this study provide accurate information about the interaction of the polymer-drug compounds and nanocarriers at the atomic level, which can be useful in the design of smart drug delivery systems.
Topics & Concepts
GrapheneDrugDrug deliveryDoxorubicinSmart polymerOxidePolymerNanotechnologyNanoparticleTargeted drug deliverySolubilityAnticancer drugDistribution (mathematics)ChemistryMaterials scienceCombinatorial chemistryPharmacologyOrganic chemistryMedicineChemotherapyMathematicsSurgeryMathematical analysisGraphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryGraphene research and applications