Anodic C(sp<sup>3</sup>)–H Acyloxylation of Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp<sup>3</sup>)–O Coupling
Canlin Zou, Hongting Wu, Jiangtao He, Yunfei Hu, Weijie Deng, Xinling Li, Jinhui Hu, Yibiao Li, Yubing Huang
Abstract
An efficient anodic C(sp3)–H acyloxylation protocol has been established via intermolecular cross-dehydrogenative C(sp3)–O coupling. The protocol provides various C2-acyloxy indolin-3-ones without the addition of metal catalysts and external oxidants because indolin-3-ones can be directly oxidized at the anode. The effective application of several medical drugs and the realization of the gram-scale experiment have proven the practicality of this protocol.
Topics & Concepts
AnodeChemistryIntermolecular forceCatalysisRealization (probability)Coupling (piping)Combinatorial chemistryMaterials scienceElectrodeMoleculeOrganic chemistryPhysical chemistryMathematicsMetallurgyStatisticsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsRadical Photochemical Reactions