Exosomal miR-222 from adriamycin-resistant MCF-7 breast cancer cells promote macrophages M2 polarization via PTEN/Akt to induce tumor progression
Wei‐xian Chen, Dandan Wang, Bei Zhu, Yi-Zhi Zhu, Lin Zheng, Zhenqing Feng, Xihu Qin
Abstract
. Collectively, our data demonstrated that chemoresistant BCa cells could remodel macrophages within tumor microenvironment by secreting exosomal miR-222, which directly targeted PTEN and caused Akt cascade activation and macrophages M2 polarization. Our findings may provide a foundation for a promising strategy of BCa treatment by targeting exosomes or exosomal miR-222.
Topics & Concepts
PTENMCF-7Cancer researchProtein kinase BBreast cancerChemistryPhosphorylationMedicinePI3K/AKT/mTOR pathwayOncologyCancerSignal transductionInternal medicineHuman breastBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases