Conjugative Transfer of Acute Hepatopancreatic Necrosis Disease-Causing pVA1-Type Plasmid Is Mediated by a Novel Self-Encoded Type IV Secretion System
Dehao Wang, Liying Wang, Dexi Bi, Jipeng Song, Guohao Wang, Ye Gao, Kathy F.J. Tang, Fanzeng Meng, Jingmei Xie, Fan Zhang, Jie Huang, Jian‐Liang Li, Xuan Dong
Abstract
species makes prevention and control more difficult, threatening the sustainable development of the aquaculture industry. In this study, we found that the horizontal transfer of pVA1-type plasmid is mediated by a novel type IV secretion system (T4SS). Our study explained the formation mechanism of pathogen diversity in AHPND. Moreover, bacterial density, temperature, and nutrient levels can regulate horizontal efficiency. We explore new ideas for controlling the spread of virulence plasmid and form the basis of management strategies leading to the prevention and control of AHPND.
Topics & Concepts
PlasmidBiologyShrimpMicrobiologySecretionToxinType three secretion systemNecrosisGeneGeneticsFisheryVirulenceBiochemistryVibrio bacteria research studiesAquaculture disease management and microbiotaAutophagy in Disease and Therapy