π–π conjugation promoted nanocatalysis for cancer therapy based on a covalent organic framework
Shuncheng Yao, Xingru Zhao, Xingyi Wan, Xueyu Wang, Tian Huang, Jiaming Zhang, Linlin Li
Abstract
in the tumor microenvironment (TME), and realize a self-oxygen-supplying PDT under near-infrared (NIR) light irradiation, simultaneously. With the full electron delocalization at the atomically dispersed active center, the catalytic activity of COF-CNT with extended π-conjugation is 6.8 times higher than that without the π-conjugated structure. The formation of the COF structure with π-π conjugation also changes the density of states (DOS) profile of its functional building block for improving PDT. Through one single treatment, it successfully achieves complete tumor regression of 4T1 breast carcinoma in mice with immunoregulation.
Topics & Concepts
Conjugated systemCovalent bondCancer therapyCatalysisNanotechnologyReactive oxygen speciesMaterials sciencePhotodynamic therapyCancerCombinatorial chemistryChemistryPolymerOrganic chemistryMedicineBiochemistryInternal medicineMetal-Organic Frameworks: Synthesis and ApplicationsCovalent Organic Framework ApplicationsAdvanced Photocatalysis Techniques