Design of (quinolin-4-ylthio)carboxylic acids as new Escherichia coli DNA gyrase B inhibitors: machine learning studies, molecular docking, synthesis and biological testing
Larysa Metelytsia, Diana Hodyna, Inga Dobrodub, Ivan Semenyuta, Mikhail Zavhorodnii, Volodymyr Blagodatny, Vasyl Kovalishyn, Oleksandr Brazhko
Topics & Concepts
Escherichia coliDNA gyraseDocking (animal)Virtual screeningPubChemIn silicoQuantitative structure–activity relationshipComputational biologyCombinatorial chemistryBiochemistryAntibacterial activityMechanism of actionChemistryBiologyDrug discoveryStereochemistryBacteriaIn vitroGeneticsGeneNursingMedicineAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsComputational Drug Discovery Methods