Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
Daozheng Yang, Gerald de Haan
Abstract
Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.
Topics & Concepts
Stem cellHaematopoiesisInflammationBiologyHematopoietic stem cellNicheBone marrowStem cell theory of agingMyeloidImmunologyCell biologyStem cell factorEcologyHematopoietic Stem Cell TransplantationImmune cells in cancerErythrocyte Function and Pathophysiology