A-DA′D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy
Ke Yang, Fei Long, Wei Liu, Zequn Zhang, Shaojing Zhao, Benhua Wang, Yingping Zou, Minhuan Lan, Jun Yuan, Xiangzhi Song, Changwei Lin
Abstract
) for type I and type II PDT, respectively. In vivo and in vitro experiments revealed that the Y16-Pr-PEG NPs significantly inhibit tumor cell growth without apparent toxic side effects under laser irradiation. Overall, the single-laser-triggered multifunctional phototheranostic Y16-Pr-PEG NPs can achieve NIR-II FLI/PAI-guided synergistic PTT/PDT against tumors.
Topics & Concepts
Photothermal therapyPhotodynamic therapyMaterials scienceSinglet oxygenPolyethylene glycolPEG ratioFluorescenceIn vivoPhotochemistryNanoparticlePEGylationLaserIrradiationFluorescence-lifetime imaging microscopyPhotoacoustic imaging in biomedicineNanotechnologyChemistryOxygenOpticsOrganic chemistryBiologyNuclear physicsPhysicsEconomicsBiotechnologyFinanceNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingPhotodynamic Therapy Research Studies