Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer's disease treatment
Akash Verma, Digambar Kumar Waiker, Neha Singh, Abhinav Singh, Poorvi Saraf, Bhagwati Bhardwaj, Pradeep Kumar, Sairam Krishnamurthy, Saripella Srikrishna, Sushant K. Shrivastava
Topics & Concepts
ChemistryLead compoundQuinazolinePharmacologyEx vivoPropidium iodideCholinesteraseMorris water navigation taskIn vivoButyrylcholinesteraseAcetylcholinesteraseBiochemistryEnzymeHippocampal formationIn vitroStereochemistryAchéNeuroscienceProgrammed cell deathApoptosisBiologyBiotechnologyMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments