Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task
Tejapratap Bollu, Samuel C. Whitehead, Nikil Prasad, Jackson Walker, Nitin Shyamkumar, Raghav Subramaniam, Brian Kardon, Itai Cohen, Jesse H. Goldberg
Abstract
To test the role of different cortical areas in holding still and reaching to targets, this study combined home-cage training with optogenetic silencing as mice engaged in a learned center-out-reach task. Inactivation specifically of contralateral caudal forelimb area (CFA) impaired corrective movements necessary to reach spatial targets to earn reward.
Topics & Concepts
NeurosciencePsychologyTask (project management)Physical medicine and rehabilitationMedicineEconomicsManagementMotor Control and AdaptationMuscle activation and electromyography studiesTranscranial Magnetic Stimulation Studies