Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management
Hanny Sawaf, Tariku T Gudura, Sylvester Dorobisz, Dianne Sandy, Xiangling Wang, Shane A. Bobart
Abstract
Chronic kidney disease (CKD) is associated with significant morbidity and mortality worldwide. In recent years, our understanding of genetic causes of CKD has expanded significantly with several renal conditions having been identified. This review discusses the current landscape of genetic kidney disease and their potential treatment options. This review will focus on cystic kidney disease, glomerular disease with genetic associations, congenital anomalies of kidneys and urinary tract (CAKUT), autosomal dominant-tubulointerstitial kidney disease (ADTKD), inherited nephrolithiasis and nephrocalcinosis.
Topics & Concepts
NephrocalcinosisMedicineKidney diseaseDiseaseKidneyCystic kidney diseaseIntensive care medicineUrinary systemBioinformaticsPathologyInternal medicineBiologyRenal Diseases and GlomerulopathiesBiomedical Research and PathophysiologyGenetic and Kidney Cyst Diseases