Influence of sex on global myocardial ischemia tolerance and mitochondrial function in circulatory death donor hearts
Qun Chen, Oluwatoyin Akande, Edward J. Lesnefsky, Mohammed Quader
Abstract
The current study shows cardiac injury is not increased in female DCD hearts following global ischemia-reperfusion compared with male DCD hearts. In addition, mitochondrial dysfunction with DCD ischemia-reperfusion is comparable in both sexes. Sex-specific immune responses and hormone receptor modulation may contribute to suboptimal outcomes in male HTx recipients with female donor hearts.
Topics & Concepts
IschemiaMedicineInternal medicineCirculatory systemCardiologyReperfusion injuryCardiac function curveHormoneHeart failureCardiac Ischemia and ReperfusionTransplantation: Methods and OutcomesOrgan Transplantation Techniques and Outcomes