Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions
Subhojit Mondal, Boris Stevanovic, Eric Butler, Jason W. Wang, Michael Meanwell
Abstract
generation of Lewis acidic silyl cations that mediate fluoride abstraction. Overall, e-THDF has significantly improved functional group tolerance over current methods and should inspire the continued development of defluorinative processes.
Topics & Concepts
SilylationElectrochemistryFluorideChemistryTrifluoromethylFunctional groupIonLewis acids and basesAbstractionMedicinal chemistryCatalysisInorganic chemistryElectrodeOrganic chemistryPhysical chemistryAlkylPolymerEpistemologyPhilosophyFluorine in Organic ChemistryAmmonia Synthesis and Nitrogen ReductionInorganic Fluorides and Related Compounds