Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
Xiaohui Si, Mi Shao, Xinyi Teng, Yue Huang, Meng Ye, Longyuan Wu, Jieping Wei, Lianxuan Liu, Tianning Gu, Junzhe Song, Ruirui Jing, Xingyuan Zhai, Xin Guo, Delin Kong, Xiu‐Jian Wang, Bohan Cai, Ying Shen, Zhaoru Zhang, Dongrui Wang, Yongxian Hu, Pengxu Qian, Gang Xiao, He Huang
Topics & Concepts
AcetylationIsocitrate dehydrogenaseHistoneCell metabolismFunction (biology)MitochondrionMetabolismCell biologyBiochemistryChemistryBiologyEnzymeGeneCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research