Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
Cheng‐Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Yubo Zhou, Jia Li, Xiaowu Dong
Topics & Concepts
Protein kinase BChemistryPI3K/AKT/mTOR pathwayPhosphorylationSignal transductionBiochemistryPharmacologyBiologyProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways