Impact of nucleic acid encapsulated MOF crystal phase on protein corona formation
Shakil Ahmed Polash, Suneela Pyreddy, Amanda N. Abraham, Sanje Mahasivam, Vipul Bansal, Linda Váradi, Gary Bryant, Ravi Shukla
Abstract
Metal–organic frameworks (MOFs) are extensively studied materials for delivering a wide range of therapeutic entities including nucleic acids. Protein corona from serum may change biological identity and properties of these therapeutic biocomposites.
Topics & Concepts
Nucleic acidCorona (planetary geology)ChemistryMaterials scienceNanotechnologyBiochemistryBiologyVenusAstrobiologyMetal-Organic Frameworks: Synthesis and ApplicationsNanoparticle-Based Drug DeliveryMetal complexes synthesis and properties