Citrus peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress
Zhangfu Fang, Yu Fu, Yang Peng, Shengren Song, Zhao-Ni Wang, Yang Yang, Yichu Nie, Hailong Han, Yanbo Teng, Weimin Xiao, J. Paul Chen, Baojin Zhou, Guoliang Ou, Jiaxing Xie, Xiaoyu Liu, Junfeng Zhang, Nanshan Zhong
Abstract
MAPK/NF-κB signaling pathways by suppressing the phosphorylation of p38, JNK and p65. Citrus peel extract is effective in decreasing oxidative stress and inflammatory responses of the peripheral lungs to DEP exposure. These protective effects further contributed to the resolution of COPD-like pathologies.
Topics & Concepts
Oxidative stressCOPDBronchoalveolar lavageLungChemistryReactive oxygen speciesIn vivoPharmacologyMedicineImmunologyBiochemistryInternal medicineBiologyBiotechnologyAir Quality and Health ImpactsChronic Obstructive Pulmonary Disease (COPD) ResearchAir Quality Monitoring and Forecasting