Tandem Strecker/C(sp<sup>3</sup>)–H amination reactions for the construction of cyanide-functionalized imidazo[1,5-<i>a</i>]pyridines with NH<sub>4</sub>SCN as a cyanating agent
Qing Yang, Xiaotong Yan, Cheng‐Tao Feng, Dexiang Chen, Zhongzhong Yan, Kun Xu
Abstract
An I 2 O 5 -mediated multicomponent reaction that allows the single-step construction of cyano-functionalized imidazo[1,5- a ]pyridines with molecular diversity was realized for the first time.
Topics & Concepts
ChemistryStrecker amino acid synthesisCyanideTandemAminationMedicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryComputational chemistryCatalysisEnantioselective synthesisComposite materialMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques