Using genetic association data to guide drug discovery and development: Review of methods and applications
Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A. W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill
Topics & Concepts
Mendelian randomizationObservational studyConfoundingPopulationRandomized controlled trialProxy (statistics)Psychological interventionComputer scienceMedicineBiologyMachine learningGeneticsPsychiatryGenetic variantsPathologyEnvironmental healthGeneGenotypeGenetic Associations and EpidemiologyStatistical Methods in Clinical TrialsBRCA gene mutations in cancer