Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization
Sanil Bhatia, Lukas V. Spanier, David Bickel, Niklas Dienstbier, Vitalij Woloschin, Melina Vogt, Henrik Pols, Beate Lungerich, Jens Reiners, Narges Aghaallaei, Daniela Diedrich, Benedikt Frieg, Julian Schliehe‐Diecks, Bertan Bopp, Franziska Lang, Mohanraj Gopalswamy, Jennifer Loschwitz, Baubak Bajohgli, Julia Skokowa, Arndt Borkhardt, Julia Hauer, Finn K. Hansen, Sander H. J. Smits, Joachim Jose, Holger Gohlke, Thomas Kurz
Abstract
(T315I) tyrosine kinase inhibitor-resistant leukemia cells, without inducing HSR.
Topics & Concepts
Hsp90Hsp90 inhibitorHeat shock proteinCell biologyChemistryGeldanamycinLeukemiaSmall moleculeCancer researchHeat shockTyrosine kinaseBiologyBiochemistrySignal transductionImmunologyGeneHeat shock proteins researchProtein Structure and DynamicsComputational Drug Discovery Methods