Síndrome inflamatória multissistêmica pediátrica: estudo seccional dos casos e fatores associados aos óbitos durante a pandemia de COVID-19 no Brasil, 2020
Laís de Almeida Relvas-Brandt, Caroline Gava, Fernanda Sindeaux Camelo, Victor Bertollo Gomes Pôrto, Ronaldo Fernandes Santos Alves, Marcela Santos Corrêa da Costa, Sandra Maria Deotti Carvalho, Greice Madeleine Ikeda do Carmo, Francieli Fontana Sutile Tardetti Fantinato, Marcelo Yoshito Wada, Yluska Myrna Meneses Brandão e Mendes, Martha Gonçalves Vieira, Roselle Bugarin Steenhouwer, Klébia Magalhães Pereira Castello Branco, Maria Verônica Câmara dos Santos, Iván Romero Rivera, Luiz Henrique Soares Nicoloso, Marco Aurélio Palazzi Sáfadi, Dalva María de Assis
Abstract
OBJECTIVE: To characterize the clinical-epidemiological profile of multisystem inflammatory syndrome in children temporally associated with COVID-19 (MIS-C), and to identify factors associated with MIS-C deaths in Brazil, 2020. METHODS: This was a cross-sectional study, using national MIS-C monitoring data. Logistical regression was performed to estimate crude and adjusted odds ratios (OR). RESULTS: Median case (n=652) age was 5 years, 57.1% were male, 52.0% were of brown race/skin color and 6.4% died. Likelihood of death was greater among those who presented O2 saturation <95% (ORa=4.35 - 95%CI 1.69;11.20) and altered urea results (ORa=5.18 - 95%CI 1.91;14.04); likelihood of death was lower when red skin blotches were not present (ORa=0.23 - 95%CI 0.09;0.62), when anticoagulants were used (ORa=0.32 - 95%CI 0.12;0.89) and when immunoglobulins were used (ORa=0.38 - 95%CI 0.15;1.01). CONCLUSION: Fatality ratios were higher among cases that presented O2 saturation <95% and altered urea results. Fatality ratios were lower among those with red skin blotches, and those who used immunoglobulins and anticoagulants.