Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up
Alessandro Sale, Marianna Noale, Simona Cintoli, Gloria Tognoni, Chiara Braschi, Nicoletta Berardi, Stefania Maggi, Lamberto Maffei, L. Maffei, Eugenio Picano, Maria Grazia Andreassi, Adriano Angelucci, Filippo Baldacci, Laura Baroncelli, Tatjana Begenisic, P. F. Bellinvia, Nicoletta Berardi, Laura Biagi, Joyce Bonaccorsi, Enrica Bonanni, Ubaldo Bonuccelli, Andrea Borghini, Chiara Braschi, M. Broccardi, Rosa María Bruno, Matteo Caleo, Cecilia Carlesi, Luca Carnicelli, G. Cartoni, Luca Cecchetti, Maria Cristina Cenni, Roberto Ceravolo, Lucia Chico, Simona Cintoli, Giovanni Cioni, Marta Coscia, Mario Costa, Giovanna D’Angelo, Paola D’Ascanio, Michele De Nes, Serena Del Turco, Elisa Di Coscio, Micaela Galante, Nicole Di Lascio, Francesco Faita, Irene Falorni, Ugo Faraguna, Alessandra Fenu, Loredana Fortunato, Roberto Jorge da Silva Franco, Luna Gargani, R. Gargiulo, Lorenzo Ghiadoni, Filippo Sean Giorgi, R. Iannarella, Caterina Iofrida, Claudia Kusmic, Federica Limongi, Michelangelo Maestri, Monica Maffei, Stefania Maggi, Michele Mainardi, Lilia Mammana, Alberto Marabotti, Veronica Mariotti, Erika Melissari, Antonella Mercuri, Silvestro Micera, Sabrina Molinaro, Roberto Narducci, Teresa Navarra, Marianna Noale, Cristina Pagni, Sara Palumbo, Rosa Pasquariello, Silvia Pellegrini, Pietro Pietrini, Tommaso Pizzorusso, Andrea Poli, Lorenza Pratali, Alessandra Retico, Emiliano Ricciardi, Giuseppina Rota, Alessandro Sale, Silverio Sbrana, Gaia Scabia, Maria Chiara Scali, D. Scelfo, Rosa Sicari, Gabriele Siciliano, Francesco Stea, Stefano Taddei, Gloria Tognoni, Alessandro Tonacci, Michela Tosetti, Stefano Turchi, L. Volpi
Abstract
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The 'Train the Brain' programme is a combined motor and cognitive intervention previously shown to markedly improve cognitive functions in MCI individuals compared to non-trained MCI controls, as assessed at the end of the 7-month intervention. Here, we extended the previous analyses to include the long-term effects of the intervention and performed a data disaggregation by gender, education and age of the enrolled participants. We report that the beneficial impact on cognitive functions was preserved at the 14-month follow-up, with greater effects in low-educated compared to high-educated individuals, and in women than in men.