Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease
Xilei Xie, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jinyan Liu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang, Bo Tang
Abstract
A two-photon fluorescent probe enabled in situ visualization of overwhelming peroxynitrite flux during amyloid-β-induced neuronal ferroptosis and cerebral peroxynitrite stress in live mice with Alzheimer's disease.
Topics & Concepts
PeroxynitriteFluorophoreFluorescenceChemistryTwo-photon excitation microscopyPhotochemistryAmyloid βBiophysicsAmyloid (mycology)DiseaseBiochemistryMedicinePathologySuperoxideBiologyOpticsPhysicsInorganic chemistryEnzymeAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsMolecular Sensors and Ion Detection