Screening on-chip fabricated nanoparticles for penetrating the blood–brain barrier
Qinghong Hou, Li‐Na Zhu, Le Wang, Xiaoyan Liu, Feng Xiao, Yangzhouyun Xie, Wenfu Zheng, Xingyu Jiang
Abstract
We synthesized a series of brain-targeting drug nanocarriers on multi-channel syringe pump-integrated microfluidic chips, and evaluated their performance in penetrating the blood–brain barrier by in vitro and in vivo experiments.
Topics & Concepts
Blood–brain barrierInternalizationIn vivoCentral nervous systemIn vitroReceptorNanoparticleChemistryNeuroscienceNanotechnologyMaterials scienceBiologyBiochemistryBiotechnologyNeuroscience and Neural EngineeringLipid Membrane Structure and BehaviorRNA Interference and Gene Delivery