TNF-α-activated eNOS signaling increases leukocyte adhesion through the <i>S</i>-nitrosylation pathway
Gaynor Aguilar, Francisco Córdova, Tania Köning, José Sarmiento, Mauricio P. Borić, Konstantin G. Birukov, Jorge Cancino, Manuel Varas‐Godoy, Andrea Soza, Natascha G. Alves, Patricio E. Mujica, Walter N. Durán, Pamela Ehrenfeld, Fabiola A. Sánchez
Abstract
Contrary to the well-established inhibitory role of NO in leukocyte adhesion, we demonstrate a positive role of nitric oxide in this process. We demonstrate that NO induced by eNOS after TNF-α treatment induces early leukocyte adhesion activating the S-nitrosylation pathway. Our data suggest that PKCζ S-nitrosylation may be a key step in this process.
Topics & Concepts
S-NitrosylationNitric oxideEnosCell biologyAdhesionTumor necrosis factor alphaChemistryNitrosylationSignal transductionImmunologyBiologyBiochemistryNitric oxide synthaseEnzymeOrganic chemistryCysteineNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsCell Adhesion Molecules Research