Synthesis of 1,8-Dioxo-decahydroacridine Derivatives <i>via</i> Ru-Catalyzed Acceptorless Dehydrogenative Multicomponent Reaction
Nandita Biswas, Dipankar Srimani
Abstract
A Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.
Topics & Concepts
Combinatorial chemistryCatalysisChemistrySubstrate (aquarium)Scope (computer science)Reaction conditionsDeuteriumComputer scienceOrganic chemistryPhysicsGeologyProgramming languageQuantum mechanicsOceanographyAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCatalytic C–H Functionalization Methods