Discovery of anti-hepatoma agents from 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine by inhibiting PI3K/AKT/NF-κB pathway activation
Yan-Qiu Zhou, Yue Sun, Hanlin Luo, Zhongfei Gao, Hongqin Zhang, Qingguo Meng, Xianyong Bai, Gui‐Ge Hou, Yun Hou
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayProtein kinase BPhosphorylationPyrimidineApoptosisToxicityDocking (animal)Caspase 3NF-κBCancer researchCell biologyBiochemistryProgrammed cell deathBiologyNursingOrganic chemistryMedicineQuinazolinone synthesis and applicationsCytokine Signaling Pathways and InteractionsCancer Mechanisms and Therapy