Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα) <sub>8</sub> Barrel Enzymes of Histidine and Tryptophan Biosynthesis
Adrian Romero‐Rivera, Marina Corbella, Antonietta Parracino, Wayne M. Patrick, Shina Caroline Lynn Kamerlin
Abstract
-barrel scaffolds. Finally, our work reemphasizes the potential of engineering loop dynamics as a tool to artificially manipulate the catalytic repertoire of TIM-barrel proteins.
Topics & Concepts
ChemistryMolecular dynamicsTriosephosphate isomeraseHistidineActive siteIsomeraseContext (archaeology)Ligand (biochemistry)StereochemistryEnzymeBiophysicsBiochemistryBiologyComputational chemistryReceptorPaleontologyProtein Structure and DynamicsEnzyme Structure and FunctionBacterial Genetics and Biotechnology