Photoinduced Decarboxylative Difluoroalkylation and Perfluoroalkylation of α-Fluoroacrylic Acids
Xiaoyu Lu, Rui Huang, Zizhen Wang, Xiang Zhang, Fan Jiang, Gui-Xian Yang, Fu-Yi Shui, Meng-Xue Su, Yanxi Sun, Hai‐Lun Sun
Abstract
Herein, a novel and practical methodology for the photoinduced decarboxylative difluoroalkylation and perfluoroalkylation of α-fluoroacrylic acids is reported. A wide range of α-fluoroacrylic acids can be used as applicable feedstocks, allowing for rapid access to structurally important difluoroalkylated and polyfluoroalkylated monofluoroalkenes with high Z-stereoselectivity under mild conditions. The protocol demonstrates excellent functional group compatibility and provides a platform for modifying complex biologically active molecules.
Topics & Concepts
ChemistryDecarboxylationOrganic chemistryCatalysisFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsPer- and polyfluoroalkyl substances research