Iridium‐Catalyzed Enantioselective Hydrogenation of Indole and Benzofuran Derivatives
Yao Ge, Zheng Wang, Zhaobin Han, Kuiling Ding
Abstract
Enantioselective hydrogenation of a broad spectrum of N-, O-, and S-containing aromatic benzoheterocycles or nonaromatic unsaturated heterocycles has been realized by using an Ir/SpinPHOX (SpinPHOX=spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline) complex as the catalyst, affording an array of the corresponding chiral benzoheterocycles (30 examples) with excellent enantioselectivities (>99 % ee in most cases) and turnover numbers up to 500.
Topics & Concepts
Enantioselective synthesisIridiumCatalysisBenzofuranOxazolineIndole testAsymmetric hydrogenationPhosphineChemistryOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisAsymmetric Synthesis and Catalysis