Maturation of lipid metabolism in the fetal and newborn sheep heart
Rachel Drake, Samantha Louey, Kent L. Thornburg
2023American Journal of Physiology-Regulatory, Integrative and Comparative Physiology10 citationsDOIOpen Access PDF
Abstract
This study characterized the previously unknown expression patterns of genes that regulate the metabolism of free fatty acids in the perinatal sheep myocardium. This study shows that the prenatal myocardium prepares for the dramatic switch from carbohydrate metabolism to near complete reliance on free fatty acids postnatally. Fetal and neonatal cardiomyocytes also demonstrate differing lipid storage mechanisms where fetal cardiomyocytes form larger lipid droplets compared with newborn cardiomyocytes.
Topics & Concepts
Lipid metabolismFetusMetabolismLipid dropletEndocrinologyInternal medicineBiologyChemistryBiochemistryPregnancyMedicineGeneticsCardiovascular Function and Risk FactorsBirth, Development, and HealthAdipose Tissue and Metabolism