Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis <i>in vitro</i> and <i>in vivo</i>
Jiawen Fan, Weiyong Shen, Sora Lee, Ashish Easow Mathai, Rui Zhang, Gezhi Xu, Mark C. Gillies
Abstract
Inhibiting Notch signaling might be an effective way to prevent retinal fibrosis. This study is of clinical significance in developing a treatment for preventing fibrosis in proliferative vitreoretinopathy, proliferative diabetic retinopathy and wet age-related macular degeneration.
Topics & Concepts
Notch signaling pathwayCell biologySignal transductionChemistryNotch proteinsProteasesExtracellular matrixDownregulation and upregulationTransforming growth factorBiologyCancer researchBiochemistryGeneEnzymeRetinal Development and DisordersOcular Disorders and TreatmentsRetinal and Macular Surgery