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SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF-κB pathway

Yun Zhou, Song Yue, Lihua Li, Jiahua Zhang, Lei Chen, Jun Chen

2024Cellular Signalling13 citationsDOI

Topics & Concepts

Sphingomyelin phosphodiesteraseGene silencingPalmitoylationSmall hairpin RNAInflammationAcid sphingomyelinaseGene knockdownBiologyDownregulation and upregulationSmall interfering RNARetinalEndocrinologyCell biologyChemistryInternal medicineMolecular biologyTransfectionImmunologyMedicineSphingomyelinBiochemistryEnzymeCholesterolApoptosisCysteineGeneRetinal Diseases and TreatmentsSphingolipid Metabolism and SignalingGlaucoma and retinal disorders
SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF-κB pathway | Litcius