<i>In–Vitro</i> Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM**
Ali Aydın, Salih Ökten, Sultan Erkan, Merve Bulut, Evrencan Özcan, Ahmet Tutar, Tamer Eren
Abstract
Abstract The present study describes mono substituted indeno[1,2‐b]quinolines ( 3 a – c and 5 ) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC 50 values 1.1–29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2‐b]quinoline amines ( 3 a – c and 5 ) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×10 3 –1.1×10 5 M −1 . The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi‐criteria decision‐making methodology (MCDM) indicated that the mono substituted indeno[1,2‐b]quinoline amine derivatives, especially 3 a and 5 , exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.