Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies
Hamada S. Abulkhair, Abdallah Turky, Adel Ghiaty, Hany E. A. Ahmed, Ashraf H. Bayoumi
Topics & Concepts
ChemistryApoptosisCytotoxicityDocking (animal)MTT assayIC50Cancer cellDoxorubicinStereochemistryIn vitroCell cultureCell cycleMoietyBiochemistryActive siteEnzymeCancerBiologyChemotherapyNursingMedicineGeneticsProtein Degradation and InhibitorsCancer Mechanisms and TherapyQuinazolinone synthesis and applications