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Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Verena Fath, Norbert Kockmann, Jürgen C. Otto, Thorsten Röder

2020Reaction Chemistry & Engineering49 citationsDOIOpen Access PDF

Abstract

Comparing an enhanced simplex algorithm with model-free design of experiments, this work presents a flexible platform for multi-objective, real-time optimisation.

Topics & Concepts

MicroreactorSimplex algorithmComputer scienceSimplexWork (physics)Process engineeringEngineeringAlgorithmChemistryMechanical engineeringLinear programmingMathematicsOrganic chemistryGeometryCatalysisInnovative Microfluidic and Catalytic Techniques InnovationProcess Optimization and IntegrationAdvanced Control Systems Optimization