Single nucleotide polymorphisms of taste genes and caries: a systematic review and meta-analysis
Luiz Alexandre Chisini, Mariana Gonzalez Cademartori, Marcus Cristian Muniz Conde, Francine dos Santos Costa, Luana Carla Salvi, Luciana Tovo‐Rodrigues, Marcos Britto Corrêa
Abstract
OBJECTIVE: The aim of the present study was to systematically review the literature investigating the single nucleotide polymorphisms (SNP) related to taste genes and their influence on caries. MATERIAL AND METHODS: Search was performed in five databases to respond to the question: 'Are the polymorphisms of taste genes associated with dental caries?'. Studies in humans were included. Assessment of quality of studies, meta-analysis and sensitivity analysis were performed. RESULTS: gene. The results suggest an effect of the heterozygote genotype (CG), which was associate with low caries experience (OR = 0.35 CI95% [0.17-0.75]). However, the genotype GG was not associated (OR = 0.17 CI95% [0.03-1.04]). Sensitivity analysis showed an important influence of one study in the results. CONCLUSIONS: SNP of taste genes seems to be associated with caries experience. Causal inferences should be interpreted with caution and the results must be replicated in different populations.