Lycibarbarines A–C, Three Tetrahydroquinoline Alkaloids Possessing a Spiro-Heterocycle Moiety from the Fruits of <i>Lycium barbarum</i>
Hui Chen, Jiang-Bo Kong, Li Zhang, Huihui Wang, Yan-Gang Cao, Mengnan Zeng, Meng Li, Yan‐Jun Sun, Kun Du, Gui‐Min Xue, Ya Wu, Xiaoke Zheng, Weisheng Feng
Abstract
Three tetrahydroquinoline alkaloids, lycibarbarines A–C (1–3), possessing a unique tetracyclic tetrahydroquinoline–oxazine–ketohexoside fused motif, were isolated from the fruits of Lycium barbarum. Their structures were determined by spectroscopic analysis and quantum-chemical calculations. Compounds 1 and 3 exhibited neuroprotective activity when evaluated for corticosterone-induced injury by reducing the apoptosis of PC12 cells through the inhibition of caspase-3 and caspase-9.
Topics & Concepts
LyciumChemistryMoietyStereochemistryNeuroprotectionQuantum chemicalMoleculeOrganic chemistryPharmacologyPathologyAlternative medicineMedicinePhytochemical Studies and BioactivitiesPlant-based Medicinal ResearchBerberine and alkaloids research