Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei‐Lin Go, Hao Fan, Eric Chun Yong Chan
Topics & Concepts
ChemistryGlutathioneCYP3A4MetaboliteCytochrome P450CYP3ANon-competitive inhibitionKetoconazoleCYP2B6BiochemistryEnzymePharmacologyMedicineDermatologyAntifungalPharmacogenetics and Drug MetabolismPI3K/AKT/mTOR signaling in cancerDrug Transport and Resistance Mechanisms