Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
Rosa M. Álvarez, Ana Belén Garcı́a, Concepción Riesco‐Fagundo, J. I. Martı́n, Carmen Varela, Antonio R. Hergueta, Esther González Cantalapiedra, Julen Oyarzábal, Bruno Di Geronimo, Milagros Lorenzo, María I. Albarrán, Antonio Cebriá, David Cebrián, Sonia Martı́nez, Carmen Blanco‐Aparicio, Joaquı́n Pastor
Topics & Concepts
PI3K/AKT/mTOR pathwayChemistrySmall moleculeKinaseDrug discoveryProtein kinase BCell growthPharmacologyIn vitroIn vivoPhosphorylationSignal transductionCancer researchBiochemistryBiologyBiotechnologyPI3K/AKT/mTOR signaling in cancerClick Chemistry and ApplicationsSynthesis and biological activity