Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model
Ke Zhang, Yangbin Xu, Yuxin Yang, Mengmeng Guo, Ting Zhang, Bo Zong, Shuhong Huang, Langda Suo, Baohua Ma, Xiaolong Wang, Yujiang Wu, Daniel Brügger, Yulin Chen
Abstract
was negatively correlated with the hindgut barrier gene expression. This study demonstrates how weaning stress can affect key host-microbe interaction regulators in the hindgut, in a lysophosphatidylcholine dependent and independent manner. Furthermore, based on our mice data, these results are transferable to other mammal species.
Topics & Concepts
BiologyWeaningHindgutBarrier functionMucin 2MicrobiomeInternal medicineApoptosisBacteroidesAndrologyEndocrinologyMicrobiologyGene expressionGeneBiochemistryCell biologyBacteriaGeneticsBotanyMidgutMedicineLarvaGut microbiota and healthProbiotics and Fermented FoodsEffects of Environmental Stressors on Livestock