A novel catalyst‐free mechanochemical protocol for the synthesis of 2,3‐dihydro‐1<i>H</i>‐perimidines
Nissy Ann Harry, Sankaran Radhika, Mohan Neetha, Gopinathan Anilkumar
Abstract
Abstract A rapid, efficient, and green grinding assisted method for the synthesis of 2,3‐dihydro‐1 H ‐perimidines has been developed. 1,8‐Diaminonaphthalene and aldehydes were ground using mortar and pestle for 5 minutes affording the product in moderate to excellent yields. The methodology minimises the use of conventional workup and column chromatographic techniques.
Topics & Concepts
ChemistryGrindingMortarCatalysisAnnulationOrganic chemistryMetallurgyComposite materialMaterials sciencePhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation