Litcius/Paper detail

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

Anthony R. Cillo, Carly Cardello, Feng Shan, Lilit Karapetyan, Sheryl Kunning, Cindy Sander, Elizabeth A. Rush, Arivarasan Karunamurthy, Ryan Massa, Anjali Rohatgi, Creg J. Workman, John M. Kirkwood, Tullia C. Bruno, Dario A.A. Vignali

2024Cell152 citationsDOIOpen Access PDF

Topics & Concepts

BiologyCytotoxic T cellBlockadeImmunityCD8Cell biologyGene expressionGeneLagCancer researchImmunologyImmune systemGeneticsReceptorIn vitroComputer networkComputer scienceCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and Interaction