Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
Anthony R. Cillo, Carly Cardello, Feng Shan, Lilit Karapetyan, Sheryl Kunning, Cindy Sander, Elizabeth A. Rush, Arivarasan Karunamurthy, Ryan Massa, Anjali Rohatgi, Creg J. Workman, John M. Kirkwood, Tullia C. Bruno, Dario A.A. Vignali
Topics & Concepts
BiologyCytotoxic T cellBlockadeImmunityCD8Cell biologyGene expressionGeneLagCancer researchImmunologyImmune systemGeneticsReceptorIn vitroComputer networkComputer scienceCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and Interaction